Paxlovid (Covid treatment): indications, side effects

Pfizer’s Paxlovid drug is indicated for Covid infection and reduces the risk of hospitalization by 85%. Among the side effects reported, arterial hypertension was observed in 5 of her treated patients.

of pax robid It’s a drug manufactured by a laboratory. Pfizer administered Orally (tablet).of prescription end at the first sign of infection COVID To avoid serious forms. Available from February 2022 in franceat the pharmacy. On 25 April 2022, health authorities (have) I was speaking agree to repay of this treatment. In a study conducted by EPI-PHARE, more than 12,000 patients in France who were at severe risk of Covid-19 in the first half of 2022 received Paxlovid. “Due to the low rate of feedback, the efficacy data collected by the laboratory at this stage do not provide additional information regarding the actual efficacy of paxlovid.“, shows ANSM for a report published on September 13, 2022. Paxlovid includes: taboo Please check before taking.this drug treatment comes In addition to vaccination, but not as a replacement. What is Constitution pax robid? What are the signs? How effective is it against Covid? Medications to avoid (dangerous drug interactions)? what is he price ?his refund? Its side effects?

Definition: What is Pax Rovid?

American pharmaceutical company Pfizer evolved antiviral therapy, sold under the name of pax robid made of nilmatrell building And of RitonavirSupplied in pill form to be taken as soon as possible after a positive diagnosis of Covid-19, Within 5 days After the onset of symptoms. The treatment targets and inhibits the action of her 3C-like protease, an enzyme necessary for viral replication, thereby blocking SARS-CoV-2 replication in the body. Marketing Authorization (AMM) was granted on January 28, 2022.

Photo of Pax Rovid's box
Photo of Pax Rovid’s box © Ministry of Health

What are the Pax Lovid indications for Covid?

Paxlovid treatment is reserved for people at risk for severe forms of Covid-19.should start with 5 days after the onset of Covid symptoms. To be eligible, patients must meet all of the following criteria:

  • be over 18 years old
  • Positive SARS-CoV-2 test (RT-PCR or antigen)
  • First appearance of symptoms attributed to COVID-19 illness < 5 days
  • Patients who do not require oxygen therapy due to COVID-19
  • Patients at high risk of progressing to severe form of COVID-191
  • Lack of contraindications to treatment
  • Evaluate the risk of drug interactions and initiate treatment as deemed feasible by the prescriber
  • Patients are clearly informed of the procedures for administering this treatment

How to get paxlovid at the pharmacy?

Pax Rovid is The first cure for Covid-19 available in town pharmacies.Can be prescribed by a general practitioner ever since February 3, 2022. Town pharmacy Prescription presentation Mention the bar code that allows the pharmacist to confirm that the eligibility for the treatment has been verified by the prescribing physician. In this way, in consideration of the timing of payment, it is necessary to go to your family pharmacist as soon as symptoms begin to appear after a medical examination in order to adhere to taking medicine within 5 days after the onset of symptoms.

How effective is it against Covid and Omicron?

According to health officials, Pax Lovid “Retains antiviral activity against various variants“. “The data available to assess the efficacy of this treatment are Approximately 85.2% reduced risk of progression to severe form of Covid-19 (hospitalization or death) after his administration. ” Additionally, Paxlovid’s mechanism of action is expected to maintain efficacy against various variants, including Omicron. Preliminary in vitro data indeed suggest that the currently circulating mutant of concern is amenable to treatment.

What is the composition of Paxlovid?

Paxlovid is composed of two molecules:

► First PF-07321332 It is an active agent that interferes with the replication of viral proteins.

► The second is Ritonavir, protease inhibitor, usually used to treat HIV infection. “HIV is not related to coronaviruses and replication of its genetic material occurs by a different mechanism.but it produces He also A polyprotein that must be cut 9 times each protease form new virus particles,” explains an article published in the journal Medicine Science in June 2020.

Paxlovid prevents the coronavirus protease from replicating.

Proteases are virus-specific enzymes Acts on viral proteins to promote viral replicationTherefore, the action of proteases must be reduced or prevented in order to stop viral replication.Coronaviruses have two proteases, one of which is SARS-CoV-2, 3CLIt is this protease that the oral treatment Paxlovid acts upon.

What is the dosage of paxlobid?

The recommended dose of Paxlovid® is 300mg PF-07321332 (2 tablets of 150mg) and Ritonavir 100mg (1 tablet 100mg), be sure to take them together (3 tablets total,Orally, 2 times a day for 5 days). Paxlovid can be taken with or without food. Tablets should be swallowed whole and should not be chewed, broken or crushed. After a positive direct virological screening test (PCR or TAG) for SARS-CoV-2, it should be administered as soon as possible and no later than 5 days after the onset of symptoms.

What are the drug interactions of paxlobid?

Concomitant use of PAXLOVID is contraindicated for certain therapies. Dose adjustments or temporary discontinuation of certain other drugs may be considered during antiviral therapy.

Paxlovid Drug Interactions
Paxlovid Drug Interactions © Ministry of Solidarity and Health

What are the side effects of Paxlovid?

Of the patients who participated in the Pfizer study published in November 2021 and who received paxlovid, 1.7% experienced serious adverse events and had to stop treatment. Ritonavir, the active substance in this drug, can actually cause side effects such as:

  • diarrhea,
  • nausea and vomiting
  • stomach ache
  • sore throat and cough,
  • headache or dizziness
  • skin rash or itching
  • Disturbances in sugar and fat metabolism with (called) abnormal fat redistribution observed after months of treatment lipodystrophy)
  • Toxicity to the liver (increased transaminases) and pancreas.

In a report published on September 2, 2022, the Pharmaceuticals Agency reports: 103 side effects Reported after using Paxlovid: 64% had non-serious effects. 30% severely affected, 6% fatalKnown effects include changes in taste and gastrointestinal disturbances. But the new signal is “investigated”. high blood pressure. 5 cases It has been documented since the Pax Lovid follow-up began. Hypertension was transient in most cases. One serious case in his 70s was reported in which he had to be hospitalized for dyspnea and malignant hypertension associated with myeloma treated with the drug Kyprolis. But ANSM believes:The role of Paxlovid appears to be less than that of Kyprolis, which is known to raise blood pressure.“Nevertheless, this signal should be monitored carefully.

What are the contraindications of Paxlovid?

This antiviral drug is contraindicated in persons with severe hepatic impairment or severe renal impairment (eGFR < 30 ml/min), including patients with end-stage renal disease undergoing hemodialysis. Dose adjustment is required in patients with moderate renal impairment.Moreover, it is not Paxlovid is not recommended for use in women of childbearing potential who are pregnant or not using contraception. Breastfeeding should be discontinued during treatment with PAXLOVID® and as a precaution for 7 days after treatment ends. Ritonavir use may reduce the effectiveness of combined hormonal contraceptives. Patients using combined hormonal contraceptives should be advised to use effective alternative or additional “barrier” contraception during treatment with PAXLOVID® and until the menstrual cycle after discontinuation of PAXLOVID®. there is.

What is the price of Pax Lovid?

The price of Paxlovid tablets is unknown. Nevertheless, Pfizer announced in a press release: Tiered pricing based on income levels in each country To ensure equitable access and affordability for all. In other words, upper-middle-income countries will pay more than low-income countries.Launched Specialty Pack Lovid® (PF-07321332 150mg/ritonavir 100mg film-coated tablet) free Health facilities and pharmacies. So users can take advantage of this in a fully supported way.

Pax Lobid redemption?

On April 25, 2022, HAS made a decision in favor of reimbursement for this treatment. “It confirms the progress of this drug by giving it a level 3 improvement in actual effectiveness (ASMR). Registering reimbursement for this treatment should encourage prescribing of Paxlovid® in community health care and facilitate patient access. In addition, general practitioners can rely on Rapid Responses issued by HAS to prescribe this drug. ” Specify permissions in the press release.

sauce

– Covid-19: Early access to Paxlovid® accepted as curative treatment. I have Press release dated January 21, 2022.

– Pfizer’s novel COVID-19 oral antiviral treatment candidate reduced the risk of hospitalization or death by 89% in an interim analysis of the Phase 2/3 EPIC-HR study on November 5, 2021.

– Targeting the key protease of SARS-CoV-2 to produce effective drugs against this coronavirus, Medical Sciences, June 2020.

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